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Description:
1-Hydroxybenzotriazole monohydrate is a white crystalline solid commonly used as a coupling reagent in peptide synthesis and other organic transformations. It enhances the efficiency of amide bond formation by suppressing racemization and stabilizing active esters. This hydrated form is particularly favored for its better handling characteristics and ease of dissolution. It is used extensively in pharmaceutical R&D and industrial peptide manufacturing. Due to its potential for explosive decomposition under heat or friction, it must be handled with strict safety precautions.
Description:
1-Hydroxybenzotriazole monohydrate is a white crystalline solid commonly used as a coupling reagent in peptide synthesis and other organic transformations. It enhances the efficiency of amide bond formation by suppressing racemization and stabilizing active esters. This hydrated form is particularly favored for its better handling characteristics and ease of dissolution. It is used extensively in pharmaceutical R&D and industrial peptide manufacturing. Due to its potential for explosive decomposition under heat or friction, it must be handled with strict safety precautions.
Product Summary:
CAS Number: 123333-53-9
Molecular Formula: C6H5N3O·H2O
Molecular Weight: 155.14 g/mol
Synonyms: HOBt·H2O
Packaging: 25 kg fiber drum or HDPE container
Solubility: Soluble in DMF, DMSO, methanol
Storage: Store in cool, dry place, away from oxidizers
Toxicity: May cause irritation; handle with care
Applications:
Coupling reagent in peptide synthesis
Intermediate in drug synthesis
Research and development in organic chemistry
