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1-Hydroxybenzotriazole anhydrous is a potent acylation catalyst and condensation agent used primarily in peptide bond formation. It prevents racemization and improves yields in carbodiimide-mediated coupling reactions. The anhydrous form is highly reactive and moisture-sensitive, often used in strictly anhydrous conditions for high-purity synthesis. It is valuable in the synthesis of pharmaceutical peptides, esters, and complex small molecules.
Description:
1-Hydroxybenzotriazole anhydrous is a potent acylation catalyst and condensation agent used primarily in peptide bond formation. It prevents racemization and improves yields in carbodiimide-mediated coupling reactions. The anhydrous form is highly reactive and moisture-sensitive, often used in strictly anhydrous conditions for high-purity synthesis. It is valuable in the synthesis of pharmaceutical peptides, esters, and complex small molecules.
Product Summary:
CAS Number: 2592-95-2
Molecular Formula: C6H5N3O
Molecular Weight: 135.12 g/mol
Synonyms: HOBt
Packaging: 25 kg fiber drum
Solubility: Soluble in polar organic solvents
Storage: Store in a dry, inert atmosphere
Toxicity: Explosive when dry; handle under controlled conditions
Applications:
Amide bond formation in peptide synthesis
Synthesis of esters and activated carboxylic derivatives
Pharmaceutical R&D
